Development of a recombinant epsilon toxoid vaccine against enterotoxemia and its use as a combination vaccine with live attenuated sheep pox virus against enterotoxemia and sheep pox.

نویسندگان

  • Dev Chandran
  • Sureddi Satyam Naidu
  • Parthasarathy Sugumar
  • Gudavalli Sudha Rani
  • Shahana Pallichera Vijayan
  • Deepika Mathur
  • Lalit C Garg
  • Villuppanoor Alwar Srinivasan
چکیده

Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were protected against enterotoxemia, with potency values of >5 IU being protective. Further, the use of this construct in a combination vaccine against sheep pox resulted in the sheep being protected against both sheep pox and enterotoxemia.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 17 6  شماره 

صفحات  -

تاریخ انتشار 2010